Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey
Author:
Yoshida Akira1ORCID, Li Yuan2, Maroufy Vahed2, Kuwana Masataka1ORCID, Sazliyana Shaharir Syahrul3, Makol Ashima4, Sen Parikshit5, Lilleker James B67ORCID, Agarwal Vishwesh8, Kadam Esha9, Akawatcharangura Goo Phonpen10, Day Jessica111213ORCID, Milchert Marcin14ORCID, Chen Yi-Ming15, Dey Dzifa16ORCID, Velikova Tsvetelina17, Saha Sreoshy18, Edgar Gracia-Ramos Abraham19ORCID, Parodis Ioannis2021ORCID, Nikiphorou Elena2223, Tan Ai Lyn2425ORCID, Nune Arvind26ORCID, Cavagna Lorenzo27, Toro Gutiérrez Carlos Enrique28, Caballero-Uribe Carlo Vinicio29, Saavedra Miguel A30, Shinjo Samuel Katsuyuki31, Ziade Nelly3233ORCID, El Kibbi Lina34, Knitza Johannes35ORCID, Distler Oliver36ORCID, Chinoy Hector373839ORCID, Agarwal Vikas40, Aggarwal Rohit41ORCID, Gupta Latika374243ORCID, , Griger Zoltán, Kardes Sinan, Vince Melinda Nagy, Singh Yogesh Preet, Ranjan Rajiv, Jain Avinash, Pandya Sapan C, Pilania Rakesh Kumar, Sharma Aman, Manesh Manoj M, Gupta VikasORCID, Kavadichanda Chengappa G, Patro Pradeepta Sekhar, Ajmani Sajal, Phatak Sanat, Goswami Rudra Prosad, Chowdhury Abhra Chandra, Mathew Ashish Jacob, Shenoy Padnamabha, Asranna Ajay, Bommakanti Keerthi Talari, Shukla Anuj, Pande Arunkumar R, Chandwar Kunal, Ghodke Akanksha, Boro Hiya, Fazal Zoha Zahid, Vaidya Binit, Cansu Döndü Üsküdar, Yıldırım Reşit, Gasparyan Armen Yuri, Del Papa Nicoletta, Sambataro Gianluca, Fabiola Atzeni, Govoni Marcello, Parisi Simone, Bocci Elena Bartoloni, Sebastiani Gian Domenico, Fusaro Enrico, Sebastiani Marco, Quartuccio Luca, Franceschini Franco, Sainaghi Pier Paolo, Orsolini Giovanni, De Angelis Rossella, Danieli Maria Giovanna, Venerito Vincenzo, Grignaschi Silvia, Giollo Alessandro, Alunno Alessia, Iannone Florenzo, Fornaro Marco, Traboco Lisa S, Wibowo Suryo Anggoro Kusumo, Loarce-Martos Jesús, Prieto-González Sergio, Gonzalez Raquel Aranega, Nakashima Ran, Sato Shinji, Kimura Naoki, Kaneko Yuko, Gono Takahisa, Tomaras Stylianos, Proft Fabian Nikolai, Holzer Marie-Therese, Gromova Margarita Aleksandrovna, Aharonov Or, Griger Zoltán, Hmamouchi Ihsane, El Bouchti Imane, Baba Zineb, Giannini Margherita, Maurier François, Campagne Julien, Meyer Alain, Langguth Daman, Limaye Vidya, Needham Merrilee, Srivastav Nilesh, Hudson Marie, Landon-Cardinal Océane, Zuleta Wilmer Gerardo Rojas, Arbeláez Álvaro, Cajas Javier, Silva José António Pereira, Fonseca João Eurico, Zimba Olena, Bohdana Doskaliuk, Ima-Edomwonyi Uyi, Dedeke Ibukunoluwa, Airenakho Emorinken, Madu Nwankwo Henry, Yerima Abubakar, Olaosebikan Hakeem, A. Becky, Koussougbo Oruma Devi, Palalane Elisa, So Ho, Ugarte-Gil Manuel Francisco, Chinchay Lyn, Bernaola José Proaño, Pimentel Victorio, Fathi Hanan Mohammed, Mohammed Reem Hamdy A, Harifi Ghita, Fuentes-Silva Yurilís, Cabriza Karoll, Losanto Jonathan, Colaman Nelly, Cachafeiro-Vilar Antonio, Bautista Generoso Guerra, Ho Enrique Julio Giraldo, Nunez Lilith Stange, Vergara Cristian, Báez Jossiell Then, Alonzo Hugo, Pastelin Carlos Benito Santiago, Salinas Rodrigo García, Obiols Alejandro Quiñónez, Chávez Nilmo, Ordóñez Andrea Bran, Llerena Gil Alberto Reyes, Sierra-Zorita Radames, Arrieta Dina, Hidalgo Eduardo Romero, Saenz Ricardo, Mendoza Idania Escalante, Calapaqui Wendy, Quezada Ivonne, Arredondo Gabriela, Andreoli Laura, Lini Daniele, Schreiber Karen, Patel Aarat, Pauling John D, Wincup Chris, Barman Bhupen, Tehozol Erick Adrian Zamora, Serrano Jorge Rojas, La Torre Ignacio García-De, Colunga-Pedraza Iris J, Chalico Javier Merayo, Chibuzo Okwara Celestine, Katchamart Wanruchada, Shumnalieva Russka, Hoff Leonardo Santos, Halabi Hussein, Vaidya Binit, Tanveer Hasan A T M, Salim Babur, Gheita Tamer, Chatterjee Tulika
Affiliation:
1. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine , Tokyo, Japan 2. Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston , Houston, TX, USA 3. UKM Medical Centre, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia , Kuala Lumpur, Cheras, Malaysia 4. Division of Rheumatology, Mayo Clinic , Rochester, MN, USA 5. Maulana Azad Medical College , New Delhi, Delhi, India 6. Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester , Manchester, UK 7. Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust , Salford, UK 8. Mahatma Gandhi Mission Medical College , Navi Mumbai, Maharashtra, India 9. Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital , Mumbai, Maharashtra, India 10. Department of Medicine, Queen Savang Vadhana Memorial Hospital , Chonburi, Thailand 11. Department of Rheumatology, Royal Melbourne Hospital , Parkville, VIC, Australia 12. Walter and Eliza Hall Institute of Medical Research , Parkville, VIC, Australia 13. Department of Medical Biology, University of Melbourne , Parkville, VIC, Australia 14. Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin , Szczecin, Poland 15. Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Taichung Veterans General Hospital , Taiwan 16. Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences , Accra, Ghana 17. Medical Faculty, Sofia University St Kliment Ohridski , Sofia, Bulgaria 18. Mymensingh Medical College , Mymensingh, Bangladesh 19. Department of Internal Medicine, General Hospital, National Medical Center “La Raza”, Instituto Mexicano del Seguro Social , Mexico City, Mexico 20. Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital , Stockholm, Sweden 21. Department of Rheumatology, Faculty of Medicine and Health, Örebro University , Örebro, Sweden 22. Centre for Rheumatic Diseases, King’s College London , London, UK 23. Rheumatology Department, King’s College Hospital , London, UK 24. NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust , Leeds, UK 25. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds , Leeds, UK 26. Southport and Ormskirk Hospital NHS Trust , Southport, UK 27. Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia , Pavia, Lombardy, Italy 28. Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali , Colombia 29. Department of Medicine, Hospital Universidad del Norte , Barranquilla, Atlantico, Colombia 30. Departamento de Reumatología Hospital de Especialidades Dr Antonio Fraga Mouret, Centro Médico Nacional La Raza, IMSS , Mexico City, Mexico 31. Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo , Sao Paulo, Brazil 32. Rheumatology Department, Saint-Joseph University , Beirut, Lebanon 33. Rheumatology Department, Hotel-Dieu de France Hospital , Beirut, Lebanon 34. Department of Rheumatology, Specialised Medical Center Hospital, Alfaisal University , Riyadh, Saudi Arabia 35. Medizinische Klinik 3 – Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Deutschland 36. Department of Rheumatology, University Hospital Zurich, University of Zurich , Zurich, Switzerland 37. Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, University of Manchester , Manchester, UK 38. National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, University of Manchester , Manchester, UK 39. Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust , Salford, UK 40. Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow, India 41. Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA 42. Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust , Wolverhampton, UK 43. Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust , Birmingham, UK
Abstract
Abstract
Objectives
To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database.
Methods
Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores. Factors affecting GPH and GMH scores in IIMs were identified using multivariable regression analysis.
Results
We analysed responses from 1582 IIM, 4700 non-IIM AIRD and 545 nrAID patients and 3675 controls gathered through 23 May 2022. The median GPH scores were the lowest in IIM and non-IIM AIRD patients {13 [interquartile range (IQR) 10–15] IIMs vs 13 [11–15] non-IIM AIRDs vs 15 [13–17] nrAIDs vs 17 [15–18] controls, P < 0.001}. The median GMH scores in IIM patients were also significantly lower compared with those without autoimmune diseases [13 (IQR 10–15) IIMs vs 15 (13–17) controls, P < 0.001]. Inclusion body myositis, comorbidities, active disease and glucocorticoid use were the determinants of lower GPH scores, whereas overlap myositis, interstitial lung disease, depression, active disease, lower PROMIS Physical Function 10a and higher PROMIS Fatigue 4a scores were associated with lower GMH scores in IIM patients.
Conclusion
Both physical and mental health are significantly impaired in IIM patients, particularly in those with comorbidities and increased fatigue, emphasizing the importance of patient-reported experiences and optimized multidisciplinary care to enhance well-being in people with IIMs.
Publisher
Oxford University Press (OUP)
Cited by
2 articles.
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