Risankizumab Is Effective for The Management of Crohn’s Disease of the Pouch

Author:

Kayal Maia1ORCID,Spencer Elizabeth A2ORCID,Smyth Matthew2,Raffals Laura3ORCID,Qazi Taha4ORCID,Deepak Parakkal5ORCID,Beniwal-Patel Poonam6,Chang Shannon7,Higgins Peter8,Cross Raymond K9,Anderson Chelsea10,Long Millie1011,Herfarth Hans H1011,Dubinsky Marla C2ORCID,Barnes Edward L1011

Affiliation:

1. Division of Gastroenterology, The Icahn School of Medicine at Mount Sinai , New York, NY , USA

2. Division of Pediatric Gastroenterology, The Icahn School of Medicine at Mount Sinai , New York, NY , USA

3. Division of Gastroenterology and Hepatology, Mayo Clinic , Rochester, MN , USA

4. Division of Gastroenterology, Cleveland Clinic , Cleveland, OH , USA

5. Division of Gastroenterology, Washington University School of Medicine in St . Louis, St. Louis, MO , USA

6. Division of Gastroenterology and Hepatology, Medical College of Wisconsin , Milwaukee, WI , USA

7. Division of Gastroenterology and Hepatology, NYU Langone Health , New York, NY , USA

8. Division of Gastroenterology and Hepatology, University of Michigan , Ann Arbor, MI , USA

9. Division of Gastroenterology and Hepatology, University of Maryland School of Medicine , Baltimore, MD , USA

10. Center for Gastrointestinal Biology and Disease, University of North Carolina , Chapel Hill, NC , USA

11. Division of Gastroenterology and Hepatology, University of North Carolina , Chapel Hill, NC , USA

Abstract

Lay Summary In this prospective, multicenter observational study of highly refractory patients with Crohn’s disease of the pouch, risankizumab achieved the primary outcome of clinical remission in 50% and the more stringent secondary outcome of antibiotic- and steroid-free remission in 30.8% at 12 weeks.

Funder

Crohn’s & Colitis Foundation

National Institutes of Health

Career Development Award

Publisher

Oxford University Press (OUP)

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