Vedolizumab Does Not Affect Antibody Secreting Cell Recruitment to the Lactating Mammary Gland of Mothers With Inflammatory Bowel Disease-Reference-Cited by-同舟云学术

Vedolizumab Does Not Affect Antibody Secreting Cell Recruitment to the Lactating Mammary Gland of Mothers With Inflammatory Bowel Disease

Published:2024-02-09 Issue: Volume: Page:
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

Urrete Josef¹,Mitra Taniya¹²,Boland Brigid S¹^ORCID,Bertrand Kerri³,Chambers Christina³,Rivera-Nieves Jesús¹²^ORCID

Affiliation:

1. Division of Gastroenterology, University of California San Diego , La Jolla, CA , USA

2. GI Section, San Diego VA Medical Center (SDVAMC) , San Diego, CA , USA

3. Department of Pediatrics, Division of Environmental Science and Health, University of California San Diego , La Jolla, CA, USAñ

Abstract

Lay Summary Despite a known role for α4β7 and MAdCAM-1 for the recruitment of antibody secreting cells to the lactating mammary gland, vedolizumab which targets integrin α4β7 did not lower breastmilk IgA in lactating mothers with IBD receiving the drug. It is likely that antibody secreting cells alternatively employ α4β1 to arrest on VCAM-1 also expressed by the lactating mammary gland.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

San Diego Digestive Diseases Research Center

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izae023/56642199/izae023.pdf

Reference18 articles.

1. Breastfeeding and the risk for diarrhea morbidity and mortality;Lamberti;BMC Public Health,2011

2. The multifaceted roles of breast milk antibodies;Atyeo;Cell.,2021

3. The mucosal immune system and its integration with the mammary glands;Brandtzaeg;J Pediatr.,2010

4. New insights into the dual recruitment of IgA+ B cells in the developing mammary gland;Bourges;Mol Immunol.,2008

5. IgA ASC accumulation to the lactating mammary gland is dependent on VCAM-1 and alpha4 integrins;Low;Mol Immunol.,2010