Tofacitinib as a Rescue Therapy for Ulcerative Colitis in Pregnancy-Reference-Cited by-同舟云学术

Tofacitinib as a Rescue Therapy for Ulcerative Colitis in Pregnancy

Published:2024-04-09 Issue:5 Volume:30 Page:868-870
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

Rowan Catherine¹,Yeaman Fiona¹,Ernest-Suarez Kenneth¹^ORCID,Martin Marie-Louise¹,Panaccione Remo¹^ORCID,Shukla Tushar¹,Grossi Matt²,Vlasschaert Meghan³,Novak Kerri¹^ORCID,Seow Cynthia¹^ORCID

Affiliation:

1. Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary , Calgary , Canada

2. Obstetrics and Gynecology, Rockyview General Hospital, University of Calgary , Calgary , Canada

3. General Internal Medicine and Obstetric Medicine, Educational Director, OBIM, University of Calgary , Calgary , Canada

Abstract

Lay Summary Tofacitinib, a potentially teratogenic nonselective Janus Kinase inhibitor was used as salvage therapy for ulcerative colitis during pregnancy with corticosteroids, maintenance ustekinumab, and rectal 5-ASA therapy. Corticosteroid-free remission ensued, resulting in term delivery without congenital malformations and avoidance of colectomy.

Funder

Alberta Children’s Hospital Research Institute

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izae076/57188860/izae076.pdf

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4. Outcomes of pregnancies with maternal/paternal exposure in the tofacitinib safety databases for ulcerative colitis;Mahadevan;Inflamm Bowel Dis.,2018

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