Clinical Outcomes at 8-16 Weeks After Upadacitinib Initiation for Acute Severe Ulcerative Colitis: A Case Series in the United States-Reference-Cited by-同舟云学术

Clinical Outcomes at 8-16 Weeks After Upadacitinib Initiation for Acute Severe Ulcerative Colitis: A Case Series in the United States

Published:2024-02-26 Issue:6 Volume:30 Page:1042-1043
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

Dalal Rahul S¹^ORCID,Winter Rachel W¹,Gupta Sanchit¹,Sasson Gila F¹,Hamilton Matthew J¹,Allegretti Jessica R¹

Affiliation:

1. Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School , Boston, MA , USA

Abstract

Lay Summary In 9 patients hospitalized for acute severe ulcerative colitis, 8 were successfully discharged without the need for colectomy. Six of 7 patients with sufficient follow-up achieved steroid-free clinical remission at 8 to 16 weeks, and 1 of 2 patients achieved endoscopic response.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izae038/56757957/izae038.pdf

Reference3 articles.

1. Upadacitinib salvage therapy for infliximab experienced patients with acute severe ulcerative colitis;Gilmore;J Crohns Colitis,2023

2. Upadacitinib for acute severe ulcerative colitis;Zinger;Inflamm Bowel Dis.,2023

3. Upadacitinib as a rescue therapy in acute severe ulcerative colitis: a case report and review of the literature;Ali;Am J Case Rep.,2023

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1. Upadacitinib for Acute Severe Ulcerative Colitis: A Systematic Review;Inflammatory Bowel Diseases;2024-08-26

2. Navigating treatment resistance: Janus kinase inhibitors for ulcerative colitis;World Journal of Clinical Cases;2024-08-26

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4. Reply: In Severe Inflammatory Bowel Disease, the Onset of Effectiveness of Biologics and Small Molecules Depends More on the Medication Than on the Diagnosis;Inflammatory Bowel Diseases;2024-08-20

5. Predicting Outcome after Acute Severe Ulcerative Colitis: A Contemporary Review and Areas for Future Research;Journal of Clinical Medicine;2024-08-01