Tofacitinib Does Not Impair Sperm Quality in Men With Ulcerative Colitis

Author:

Grosen Anne1ORCID,Bellaguarda Emanuelle2,Liljeqvist-Soltic Ingela3,Skytte Anne-Bine4,Hanauer Stephen B2,Kelsen Jens5

Affiliation:

1. Department of Clinical Genetics, Aarhus University Hospital , Aarhus , Denmark

2. Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University , Chicago, IL , USA

3. Reproductive Medicine Centre, Skaane University Hospital , Malmoe , Sweden

4. Cryos International , Aarhus , Denmark

5. Department of Hepatology and Gastroenterology, Aarhus University Hospital , Aarhus , Denmark

Abstract

Lay Summary We demonstrate that tofacitinib does not adversely affect semen quality or sex hormones in male patients. These first postmarketing data for tofacitinib and semen quality are reassuring. Our study raises no safety concerns, though larger studies are needed to confirm our findings.

Funder

Digestive Health Foundation

Colitis-Crohn Denmark

Publisher

Oxford University Press (OUP)

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