Affiliation:
1. Division of Food and Nutrition, Chonnam National University, Gwangju, Republic of Korea
2. Human Ecology Research Institute, Chonnam National University, Gwangju, Republic of Korea
Abstract
ABSTRACT
Recently, extracellular microRNAs (miRNAs) from adipose tissue have been shown to be involved in the development of insulin resistance. Here, we summarize several mechanisms explaining the pathogenesis of obesity-induced insulin resistance and associated changes in the expression of obesity-associated extracellular miRNAs. We discuss how miRNAs, particularly miR-27a, miR-34a, miR-141-3p, miR-155, miR210, and miR-222, in extracellular vesicles secreted from the adipose tissue can affect the insulin signaling pathway in metabolic tissue. Understanding the role of these miRNAs will further support the development of therapeutics for obesity and metabolic disorders such as type 2 diabetes.
Funder
National Research Foundation of Korea
Publisher
Oxford University Press (OUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous),Food Science
Cited by
26 articles.
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