The impact of COVID-19 on clinical outcomes of burn patients

Author:

Walters Elliot T1,Palackic Alen123ORCID,Franco-Mesa Camila1ORCID,Shah Nikhil R1,Erickson Michael J1,Wolf Steven E1ORCID

Affiliation:

1. Department of Surgery, University of Texas Medical Branch , 301 University, Galveston, TX , USA

2. Division of Plastic , Aesthetic and Reconstructive Surgery, Department of Surgery, , Graz , Austria

3. Medical University of Graz , Aesthetic and Reconstructive Surgery, Department of Surgery, , Graz , Austria

Abstract

Abstract Background Multiple studies have shown the SARS-CoV-2 virus (COVID-19) to be associated with deleterious outcomes in a wide range of patients. The impact of COVID-19 has not been well investigated among burned patients. We suspect that patients will have worsened respiratory and thrombotic complications, ultimately leading to increased mortality. The objective of this study is to determine the impact a concurrent infection of COVID-19 has on clinical outcomes after a burn injury. Methods This is a retrospective, propensity matched, cohort study. We examined a de-identified database of electronic medical records of over 75 million patients across 75 health care associations in the United States for patients treated for thermal burns from 1 January 2020, to 31 July 2021, and those who also were diagnosed with COVID-19 infection within one day before or after injury based on International Classification of Disease, tenth revision (ICD-10) codes. Study participants included adults who were treated for a burn injury during the study period. Results We included 736 patients with burn injury and concomitant COVID-19 infection matched to 736 patients with burn injury and no concurrent COVID-19 infection (total 1472 patients, mean age 36.3 ± 24.3). We found no significant increase in mortality observed for patients with concurrent COVID-19 (OR 1.203, 95% CI 0.517–2.803; p = 0.6675). We did observe significant increase in infections (OR 3.537, 95% CI 2.798–4.471; p = 0.0001), thrombotic complications (OR 2.342, 95% CI 1.351–4.058; p = 0.0018), as was the incidence of hypertrophic scarring (OR 3.368, 95% CI 2.326–4.877; p = 0.0001). Conclusions We observed that concurrent COVID-19 infection was associated with an increase in infections, thrombosis and hypertrophic scarring but no increase in mortality in our cohort of burn patients.

Funder

Clinical and Translational Science Award

National Center for Advancing Translational Sciences

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Critical Care and Intensive Care Medicine,Dermatology,Biomedical Engineering,Emergency Medicine,Immunology and Allergy,Surgery

Reference22 articles.

1. Structural and physiological changes of the human body upon SARS-CoV-2 infection;Wu;J Zhejiang Univ Sci B,2021

2. The coagulopathy, endotheliopathy, and vasculitis of COVID-19;Iba;Inflamm Res,2020

3. The interplay between inflammatory pathways and COVID-19: a critical review on pathogenesis and therapeutic options;Choudhary;Microb Pathog,2021

4. Inflammatory and coagulative pathophysiology for the management of burn patients with COVID-19: systematic review of the evidence;Al-Benna;Annals of Burns and Fire Disasters,2021

5. Health care disparities during the COVID-19 pandemic;Andraska;Semin Vasc Surg,2021

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