Hypoxic environment of wounds and photosynthesis-based oxygen therapy

Author:

Tian Shuning12,Tan Shenyu12,Fan Mingjie12,Gong Wenlin12,Yang Tianchang12,Jiao Fangwen34,Qiao Hongzhi12ORCID

Affiliation:

1. Jiangsu Engineering Research Center for Efficient Delivery System of TCM , School of Pharmacy, , 138 Xianlin Avenue, Qixia District, Nanjing 210023 , China

2. Nanjing University of Chinese Medicine , School of Pharmacy, , 138 Xianlin Avenue, Qixia District, Nanjing 210023 , China

3. Department of Pathogen Biology , School of Medicine and Holistic Integrative Medicine, , 138 Xianlin Avenue, Qixia District, Nanjing 210023 , China

4. Nanjing University of Chinese Medicine , School of Medicine and Holistic Integrative Medicine, , 138 Xianlin Avenue, Qixia District, Nanjing 210023 , China

Abstract

Abstract The hypoxic environment is among the most important factors that complicates the healing of chronic wounds, such as venous leg ulcers, pressure injuries and diabetic foot ulcers, which seriously affects the quality of life of patients. Various oxygen supply treatments are used in clinical practice to improve the hypoxic environment at the wound site. However, problems still occur, such as insufficient oxygen supply, short oxygen infusion time and potential biosafety risks. In recent years, artificial photosynthetic systems have become a research hotspot in the fields of materials and energy. Photosynthesis is expected to improve the oxygen level at wound sites and promote wound healing because the method provides a continuous oxygen supply and has good biosafety. In this paper, oxygen treatment methods for wounds are reviewed, and the oxygen supply principle and construction of artificial photosynthesis systems are described. Finally, research progress on the photosynthetic oxygen production system to promote wound healing is summarized.

Funder

National Natural Science Foundation of China

Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources

Natural Science Research of Jiangsu Higher Education Institutions of China

Jiangsu Postgraduate Research & Practice Innovation Program

Six Talent Peaks Project of Jiangsu Province

Publisher

Oxford University Press (OUP)

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