Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti-Reference-Cited by-同舟云学术

Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti

Published:2019-01-29 Issue:4 Volume:69 Page:717-719
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Walsh Kathleen F¹^ORCID,Vilbrun Stalz Charles²,Souroutzidis Ariadne³,Delva Sobieskye²,Joissaint Guy²,Mathurin Laurent²,Ocheretina Oksana¹,Cremieux Pierre³,Pape Jean William²,Koenig Serena P⁴

Affiliation:

1. Center for Global Health, Weill Cornell Medicine, New York City, New York

2. The Haitian Group for the Study of Kaposi’s Sarcoma and Opportunistic Infections, Port-au-Prince, Haiti

3. Analysis Group, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

4. Division of Global Health Equity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

Abstract

Abstract We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.

Funder

National Institutes of Health

Fogarty International Center

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/article-pdf/69/4/717/33441368/ciz039.pdf

Reference10 articles.

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2. Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa;Jacobson;Clin Infect Dis,2011