Limited Utility of Polymerase Chain Reaction in Induced Sputum Specimens for Determining the Causes of Childhood Pneumonia in Resource-Poor Settings: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study

Author:

Thea Donald M.1,Seidenberg Phil12,Park Daniel E.34,Mwananyanda Lawrence15,Fu Wei36,Shi Qiyuan3,Baggett Henry C.78,Brooks W. Abdullah910,Feikin Daniel R.311,Howie Stephen R.C.121314,Knoll Maria Deloria3,Kotloff Karen L.15,Levine Orin S.316,Madhi Shabir A.1718,O’Brien Katherine L.3,Scott J. Anthony G.1920,Antonio Martin122122,Awori Juliet O.19,Baillie Vicky L.1718,DeLuca Andrea N.323,Driscoll Amanda J.3,Higdon Melissa M.3,Hossain Lokman10,Jahan Yasmin10,Karron Ruth A.24,Kazungu Sidi19,Li Mengying325,Moore David P.171826,Morpeth Susan C.192027,Ofordile Ogochukwu12,Prosperi Christine3,Sangwichian Ornuma7,Sawatwong Pongpun7,Sylla Mamadou28,Tapia Milagritos D.15,Zeger Scott L.29,Murdoch David R.3031,Hammitt Laura L.319,O. K. L.,L. O. S.,K. M. D.,F. D. R.,D. A. N.,D. A. J.,Fancourt Nicholas,F. W.,H. L. L.,H. M. M.,Wangeci Kagucia E.,K. R. A.,L. M.,P. D. E.,P. C.,Wu Zhenke,Z. S. L.,Watson Nora L.,Crawley Jane,M. D. R.,W. A. B.,Endtz Hubert P.,Khalequ Zaman,Goswami Doli,H. L.,J. Y.,Ashraf Hasan,H. S. R. C.,Ebruke Bernard E.,A. M.,McLellan Jessica,Machuka Eunice,Shamsul Arifin,Zaman Syed M. A.,Mackenzie Grant,S. J. A. G.,A. J. O.,M. S. C.,Kamau Alice,K. S.,Ominde Micah Silaba,K. K. L.,T. M. D.,Sow Samba O.,S. M.,Tamboura Boubou,Onwuchekwa Uma,Kourouma Nana,Toure Aliou,M. S. A.,M. D. P.,Adrian Peter V.,B. V. L.,Kuwanda Locadiah,Mudau Azwifarwi,Groome Michelle J.,Mahomed Nasreen,B. H. C.,Thamthitiwat Somsak,Maloney Susan A.,Bunthi Charatdao,Rhodes Julia,S. P.,Akarasewi Pasakorn,T. D. M.,M. L.,Chipeta James,S. P.,Mwansa James,wa Somwe Somwe,Kwenda Geoffrey,Anderson Trevor P.,Mitchell Joanne,

Affiliation:

1. Center for Global Health and Development, Boston University School of Public Health, Massachusetts;

2. Department of Emergency Medicine, University of New Mexico, Albuquerque;

3. Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

4. Milken Institute School of Public Health, Department of Epidemiology and Biostatistics, George Washington University, DC;

5. University Teaching Hospital, Lusaka, Zambia;

6. Department of Rheumatology, Johns Hopkins School of Medicine, Baltimore, Maryland;

7. Global Disease Detection Center, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi;

8. Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;

9. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

10. International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka and Matlab;

11. Division of Viral Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;

12. Medical Research Council Unit, Basse, The Gambia;

13. Department of Paediatrics University of Auckland and

14. Centre for International Health, University of Otago, Dunedin, New Zealand;

15. Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, Institute of Global Health, University of Maryland School of Medicine, Baltimore;

16. Bill & Melinda Gates Foundation, Seattle, Washington;

17. Medical Research Council: Respiratory and Meningeal Pathogens Research Unit and

18. Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa;

19. Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi;

20. Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine and

21. London School of Hygiene & Tropical Medicine, London, and

22. Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Coventry, United Kingdom;

23. Department of Epidemiology,

24. Department of International Health, Center for Immunization Research, and

25. Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

26. Department of Paediatrics & Child Health, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, South Africa;

27. Microbiology Laboratory, Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand;

28. Centre pour le Déloppement des Vaccins (CVD-Mali), Bamako, Mali;

29. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

30. Department of Pathology, University Otago and

31. Microbiology Unit, Canterbury Health Laboratories, Christchurch, New Zealand

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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