Effect of the Fit2Thrive Intervention on Patient-reported Outcomes in Breast Cancer Survivors: A Randomized Full Factorial Trial

Author:

Solk Payton1ORCID,Song Jing1,Welch Whitney A1,Spring Bonnie1,Cella David1,Penedo Frank2,Ackermann Ron1,Courneya Kerry S3,Siddique Juned1,Freeman Hannah1,Starikovsky Julia1,Mishory Abby1,Alexander Jacqueline1,Wolter Melanie1,Carden Lillian1,Phillips Siobhan M1ORCID

Affiliation:

1. Northwestern University Feinberg School of Medicine , Chicago, IL , USA

2. University of Miami Sylvester Comprehensive Cancer Center , Miami, FL , USA

3. Faculty of Kinesiology, Sport, and Recreation, University of Alberta , Edmonton, Alberta , Canada

Abstract

AbstractBackgroundModerate to vigorous physical activity (MVPA) interventions improve patient-reported outcomes (PROs) of physical and psychological health among breast cancer survivors (BCS); however, the effects of specific intervention components on PROs are unknown.PurposeTo use the Multiphase Optimization Strategy (MOST) to examine overall effects of the Fit2Thrive MVPA promotion intervention on PROs in BCS and explore whether there are intervention component-specific effects on PROs.MethodsPhysically inactive BCS [n = 269; Mage = 52.5 (SD = 9.9)] received a core intervention (Fitbit + Fit2Thrive smartphone app) and were randomly assigned to one of 32 conditions in a full factorial experiment of five components (“on” vs. “off”): (i) support calls, (ii) deluxe app, (iii) text messages, (iv) online gym, and (v) buddy. Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires assessed anxiety, depression, fatigue, physical functioning, sleep disturbance and sleep-related impairment at baseline, post-intervention (12-week), and 24-week follow-up. Main effects for all components at each time point were examined using an intention to treat mixed-effects model.ResultsAll PROMIS measures except sleep disturbance significantly improved (p’s < .008 for all) from baseline to 12-weeks. Effects were maintained at 24-weeks. The “on” level of each component did not result in significantly greater improvements on any PROMIS measure compared to the “off” level.ConclusionsParticipation in Fit2Thrive was associated with improved PROs in BCS, but improvements did not differ for “on” vs. “off” levels for any component tested. The low-resource Fit2Thrive core intervention is a potential strategy to improve PROs among BCS. Future studies should test the core in an RCT and examine various intervention component effects in BCS with clinically elevated PROs.

Funder

National Cancer Institute

Robert H. Lurie Comprehensive Cancer Center

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health,General Psychology

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