A critical appraisal of the sensitivity of in vivo genotoxicity assays in detecting human carcinogens

Author:

Zeller Andreas1,Pfuhler Stefan2,Albertini Silvio1,Bringezu Frank3,Czich Andreas4,Dietz Yasmin4,Fautz Rolf5,Hewitt Nicola J6,Kirst Annette5,Kasper Peter7

Affiliation:

1. Pharmaceutical Sciences, pRED Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse, Basel, Switzerland

2. Procter & Gamble, Global Product Stewardship, Human Safety, Mason Business Centre, Mason, OH, USA

3. Merck KGaA, Darmstadt, Germany

4. Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt, Germany

5. Kao Germany GmbH, Darmstadt, Germany

6. SWS, Wingertstrasse, Erzhausen, Germany

7. Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee, Bonn, Germany

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Toxicology,Genetics

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