Hepatitis B–CpG Vaccine Series for Healthcare Workers Who Are Hepatitis B Vaccine Nonresponders-Reference-Cited by-同舟云学术

Hepatitis B–CpG Vaccine Series for Healthcare Workers Who Are Hepatitis B Vaccine Nonresponders

Published:2024-06-17 Issue:2 Volume:79 Page:562-563
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Russ Rachel K¹,Vandehei Haley M²,Golovkina Maria I¹,Mogallapalli Harshitha³,Caldera Freddy³^ORCID,Hayney Mary S¹^ORCID

Affiliation:

1. School of Pharmacy, University of Wisconsin—Madison , Madison, Wisconsin , USA

2. Employee Health Services, UW Health , Madison, Wisconsin , USA

3. Department of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin-Madison School of Medicine and Public Health , Madison, Wisconsin , USA

Abstract

Abstract This prospective study enrolled healthcare workers (HCWs) who were nonresponders following at least 5 doses of aluminum-adjuvanted hepatitis B vaccine who received the 2-dose Heplisav-B (HepB-CpG) (Dynavax Technologies Corporation, Emeryville, CA) series. After 2 doses of HepB-CpG, 43/47 (91%) participants, and with 1 dose, 41/49 (84%) responded. HepB-CpG could be the preferred vaccine in HCW nonresponders. Clinical Trials Registration. Clinicaltrials.gov NCT04456504.

Funder

Dynavax Technologies Corporation

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciae320/58365081/ciae320.pdf

Reference5 articles.

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3. Heplisav-B in prior hepatitis B vaccine nonresponders: a case series;Williams;Mil Med,2022

4. Preventing hepatitis B virus infection among healthcare professionals: potential impact of a 2-dose versus 3-dose vaccine;Stevenson;Hum Vaccin Immunother,2021