Long-Acting Injectable Cabotegravir and Rilpivirine in a Pregnant Woman Living With Human Immunodeficiency Virus-Reference-Cited by-同舟云学术

Long-Acting Injectable Cabotegravir and Rilpivirine in a Pregnant Woman Living With Human Immunodeficiency Virus

Published:2024-05-03 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

van der Wekken-Pas Lena¹^ORCID,Weiss Fabian²,Simon-Zuber Charlotte²,Sebisch Rena²,Wiese Carmen³,van Leeuwen Elisabeth⁴,Burger David¹,Colbers Angela¹

Affiliation:

1. Department of Pharmacy, Radboud University Medical Center, Radboud Institute for Medical Innovations (RIMI) , Nijmegen , The Netherlands

2. Department of Obstetrics and Gynecology, LMU University Hospital , Munich , Germany

3. Department of Internal Medicine, MVZ München am Goetheplatz , Munich , Germany

4. Department of Gynecology, Amsterdam University Medical Center , Amsterdam , The Netherlands

Abstract

Abstract This case report describes the effects of bimonthly long-acting injectable cabotegravir (CAB)/RPV before and throughout pregnancy. CAB concentrations were comparable to those in nonpregnant individuals; RPV concentrations were 70%–75% lower. No virologic failure or vertical transmission occurred. Despite placental transfer, no congenital malformations were noted. Bimonthly long-acting injectable CAB/RPV may not be suitable for pregnant women, and monitoring of exposed infants is warranted.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciae242/58153018/ciae242.pdf

Reference17 articles.

1. Pregnancy outcomes and pharmacokinetics in pregnant women living with HIV exposed to long-acting cabotegravir and rilpivirine in clinical trials;Patel;HIV Med,2023

2. Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial;Delany-Moretlwe;Lancet,2022

3. Compassionate use of long-acting cabotegravir plus rilpivirine for people living with HIV-1 in need of parenteral antiretroviral therapy;D'Amico;HIV Med,2023

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