Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients-Reference-Cited by-同舟云学术

Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients

Published:2024-07-02 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Johnston Trevor S¹^ORCID,Hage Camille¹^ORCID,Abedon Aura T²^ORCID,Panda Snigdha¹,Alejo Jennifer L²^ORCID,Eby Yolanda³^ORCID,Segev Dorry L⁴^ORCID,Tobian Aaron A R³^ORCID,Cox Andrea L¹⁵⁶^ORCID,Werbel William A¹^ORCID,Karaba Andrew H¹^ORCID

Affiliation:

1. Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

2. Department of Surgery, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

3. Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

4. Department of Surgery, NYU Grossman School of Medicine , New York, New York , USA

5. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland , USA

6. Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

Abstract

Abstract Durability of variant neutralization in solid organ transplant recipients following Omicron-containing boosters is unknown. We report wane in XBB.1.5 neutralization by 3 months following a first bivalent booster, improved by a second booster; hybrid immunity improved peak, and duration of neutralization. Boosting at 3 to 6 months appears necessary to maintain neutralization.

Funder

Ben-Dov family

Trokhan Patterson family

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Allergy and Infectious Diseases

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciae279/58512497/ciae279.pdf

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