Revolutionizing Daptomycin Dosing: A Single 7–11-Hour Sample for Pragmatic Application-Reference-Cited by-同舟云学术

Revolutionizing Daptomycin Dosing: A Single 7–11-Hour Sample for Pragmatic Application

Published:2024-03-29 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Angelini Jacopo¹²^ORCID,Liu Shuhan³^ORCID,Giuliano Simone⁴,Flammini Sarah⁴,Martini Luca⁴,Tascini Carlo⁴,Baraldo Massimo¹²,Pai Manjunath P³^ORCID

Affiliation:

1. Clinical Pharmacology and Toxicology Institute, University Hospital Friuli Centrale ASUFC , Udine , Italy

2. Department of Medicine (DMED), University of Udine (UNIUD) , Udine , Italy

3. Department of Clinical Pharmacy, College of Pharmacy, University of Michigan , Ann Arbor, Michigan , USA

4. Infectious Diseases Division, Department of Medicine (DMED), University of Udine and Azienda Sanitaria Universitaria Friuli Centrale , Udine , Italy

Abstract

Abstract Precision daptomycin dosing faces clinical implementation barriers despite known exposure-safety concerns with the use of twice the regulatory-approved doses. We propose achieving a single 7–11-hour post-dose plasma target concentration of 30 mg/L to 43 mg/L to be a practical starting point to facilitate precision daptomycin dosing.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciae178/57349871/ciae178.pdf

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