Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality
Author:
Affiliation:
1. Department of Microbiology and Molecular Genetics and
2. Department of Pediatrics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA
Funder
National Institutes of Health
Publisher
Oxford University Press (OUP)
Subject
Immunology,General Medicine,Immunology and Allergy
Link
http://academic.oup.com/intimm/article-pdf/29/6/277/24325197/dxx035.pdf
Reference51 articles.
1. Ankylosing spondylitis;Braun;Lancet,2007
2. Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment;Brown;Arthritis Rheum,1997
3. Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1;Cortes;Nat. Commun,2015
4. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci;Cortes;Nat. Genet,2013
5. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility;Evans;Nat. Genet,2011
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