<i>Alcaligene</i>s lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue-Reference-Cited by-同舟云学术

Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue

Published:2023-11-25 Issue:1 Volume:36 Page:33-43
ISSN:1460-2377
Container-title:International Immunology
language:en
Short-container-title:

Author:

Sun Xiao¹²,Hosomi Koji¹,Shimoyama Atsushi³⁴,Yoshii Ken¹⁵,Saika Azusa¹,Yamaura Haruki³,Nagatake Takahiro¹⁶,Kiyono Hiroshi⁷⁸⁹¹⁰,Fukase Koichi³⁴,Kunisawa Jun¹²³⁴⁵¹¹¹²¹³¹⁴

Affiliation:

1. Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) , Osaka 567-0085 , Japan

2. Graduate School of Pharmaceutical Sciences, Osaka University , Suita, Osaka 565-0871 , Japan

3. Department of Chemistry, Graduate School of Science, Osaka University , Osaka 560-0043 , Japan

4. Collaborative Research Between NIBIOHN and Graduate School of Science, Forefront Research Center, Osaka University , Osaka 560-0043 , Japan

5. Graduate School of Medicine, Osaka University , Osaka 565-0871 , Japan

6. Department of Life Sciences, Laboratory of Functional Anatomy, School of Agriculture, Meiji University , Kanagawa 214-8571 , Japan

7. Division of Gastroenterology, Department of Medicine, University of California San Diego (UCSD) , San Diego, CA 92093 , USA

8. Chiba University (CU)-UCSD Center for Mucosal Immunology, Allergy and Vaccines (cMAV), UCSD , San Diego, CA 92093-0063 , USA

9. Future Medicine Education and Research Organization, Chiba University , Chiba 260-8670 , Japan

10. Department of Human Mucosal Vaccinology, Chiba University Hospital , Chiba 260-8677 , Japan

11. International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 , Japan

12. Department of Microbiology and Immunology, Kobe University Graduate School of Medicine , Kobe 650-0017 , Japan

13. Research Organization for Nano and Life Innovation, Waseda University , Tokyo 162-0041 , Japan

14. Graduate School of Dentistry, Osaka University , Suita 565-0871 , Japan

Abstract

Abstract We previously demonstrated that Alcaligenes-derived lipid A (ALA), which is produced from an intestinal lymphoid tissue-resident commensal bacterium, is an effective adjuvant for inducing antigen-specific immune responses. To understand the immunologic characteristics of ALA as a vaccine adjuvant, we here compared the adjuvant activity of ALA with that of a licensed adjuvant (monophosphoryl lipid A, MPLA) in mice. Although the adjuvant activity of ALA was only slightly greater than that of MPLA for subcutaneous immunization, ALA induced significantly greater IgA antibody production than did MPLA during nasal immunization. Regarding the underlying mechanism, ALA increased and activated CD11b+ CD103− CD11c+ dendritic cells in the nasal tissue by stimulating chemokine responses. These findings revealed the superiority of ALA as a mucosal adjuvant due to the unique immunologic functions of ALA in nasal tissue.

Funder

KAKENHI

Japan Science and Technology Agency

Japan Agency for Medical Research and Development

Ministry of Health, Labour and Welfare of Japan

Cross-ministerial Strategic Innovation Promotion Program

The University of Tokyo

Ono Medical Research Foundation

Canon Foundation

Osaka University Foundation for the Future

Publisher

Oxford University Press (OUP)

Subject

Immunology,General Medicine,Immunology and Allergy

Link

https://academic.oup.com/intimm/advance-article-pdf/doi/10.1093/intimm/dxad045/54930153/dxad045.pdf

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