CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation-Reference-Cited by-同舟云学术

CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation

Published:2021-01-06 Issue:5 Volume:33 Page:273-280
ISSN:1460-2377
Container-title:International Immunology
language:en
Short-container-title:

Author:

Kitai Yuichi¹,Ishiura Marie¹,Saitoh Kodai¹,Matsumoto Naoki¹,Owashi Kimiya¹,Yamada Shunsuke¹,Muromoto Ryuta¹,Kashiwakura Jun-ichi¹^ORCID,Oritani Kenji²,Matsuda Tadashi¹

Affiliation:

1. Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan

2. Department of Hematology, International University of Health and Welfare, Narita, Chiba, Japan

Abstract

Abstract CD47, a 50 kDa transmembrane protein, facilitates integrin-mediated cell adhesion and inhibits cell engulfment by phagocytes. Since CD47 blocking promotes engulfment of cancer cells by macrophages, it is important to clarify the mechanism of CD47 signaling in order to develop treatments for diseases involving CD47-overexpressing cancer cells, including breast cancer and lymphoma. Here, we show that CD47 plays an essential role in T-cell lymphoma metastasis by up-regulating basal RhoA activity independent of its anti-phagocytic function. CD47 interacts with AKAP13, a RhoA-specific guanine nucleotide exchange factor (GEF), and facilitates AKAP13-mediated RhoA activation. Our study shows that CD47 has a novel function on the AKAP13-RhoA axis and suggests that CD47–AKAP13 interaction would be a novel target for T-cell lymphoma treatment.

Funder

Grant-in-Aid for Scientific Research

Grant-in-Aid for Early-Career Scientists

Platform Project for Supporting Drug Discovery and Life Science Research

Basis for Supporting Innovative Drug Discovery and Life Science Research

Publisher

Oxford University Press (OUP)

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://academic.oup.com/intimm/advance-article-pdf/doi/10.1093/intimm/dxab002/36216630/dxab002.pdf

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