PBP4 activity and its overexpression are necessary for PBP4-mediated high-level β-lactam resistance

Author:

Basuino Li1,Jousselin Ambre2,Alexander J Andrew N3,Strynadka Natalie C J3,Pinho Mariana G2,Chambers Henry F1,Chatterjee Som S1

Affiliation:

1. Division of HIV/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Francisco, CA, USA

2. Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal

3. Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

Reference12 articles.

1. Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes;Macheboeuf;FEMS Microbiol Rev,2006

2. Waves of resistance: Staphylococcus aureus in the antibiotic era;Chambers;Nat Rev Microbiol,2009

3. In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus;Banerjee;Antimicrob Agents Chemother,2008

4. PBP 4 mediates high-level resistance to new-generation cephalosporins in Staphylococcus aureus;Chan;Antimicrob Agents Chemother,2016

5. Whole-genome sequencing of methicillin-resistant Staphylococcus aureus resistant to fifth-generation cephalosporins reveals potential non-mecA mechanisms of resistance;Greninger;PLoS One,2016

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