Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Author:

Sharp Gemma C123ORCID,Salas Lucas A456,Monnereau Claire789,Allard Catherine10,Yousefi Paul11,Everson Todd M12,Bohlin Jon13,Xu Zongli14,Huang Rae-Chi15,Reese Sarah E16,Xu Cheng-Jian1718,Baïz Nour19,Hoyo Cathrine2021,Agha Golareh22,Roy Ritu232425,Holloway John W26,Ghantous Akram27,Merid Simon K28,Bakulski Kelly M29,Küpers Leanne K1230,Zhang Hongmei31,Richmond Rebecca C12,Page Christian M32,Duijts Liesbeth79,Lie Rolv T3334,Melton Phillip E3536,Vonk Judith M37,Nohr Ellen A38,Williams-DeVane ClarLynda39,Huen Karen11,Rifas-Shiman Sheryl L40,Ruiz-Arenas Carlos4641,Gonseth Semira4243,Rezwan Faisal I26,Herceg Zdenko27,Ekström Sandra28,Croen Lisa44,Falahi Fahimeh30,Perron Patrice1045,Karagas Margaret R4647,Quraishi Bilal M31,Suderman Matthew12,Magnus Maria C1232,Jaddoe Vincent W V789,Taylor Jack A1448,Anderson Denise15,Zhao Shanshan16,Smit Henriette A49,Josey Michele J3950,Bradman Asa11,Baccarelli Andrea A22,Bustamante Mariona4651,Håberg Siri E52,Pershagen Göran2853,Hertz-Picciotto Irva54,Newschaffer Craig55,Corpeleijn Eva30,Bouchard Luigi5657,Lawlor Debbie A12,Maguire Rachel L2058,Barcellos Lisa F11,Davey Smith George12,Eskenazi Brenda11,Karmaus Wilfried30,Marsit Carmen J12,Hivert Marie-France404559,Snieder Harold30,Fallin M Daniele60,Melén Erik285361,Munthe-Kaas Monica C6263,Arshad Hasan646566,Wiemels Joseph L42,Annesi-Maesano Isabella19,Vrijheid Martine4641,Oken Emily40,Holland Nina11,Murphy Susan K67,Sørensen Thorkild I A16869,Koppelman Gerard H70,Newnham John P71,Wilcox Allen J14,Nystad Wenche32,London Stephanie J16,Felix Janine F789,Relton Caroline L12

Affiliation:

1. MRC Integrative Epidemiology Unit

2. School of Social and Community Medicine

3. School of Oral and Dental Sciences, University of Bristol, Bristol, UK

4. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain

5. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

6. Universitat Pompeu Fabra (UPF), Barcelona, Spain

7. The Generation R Study Group

8. Department of Epidemiology

9. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

10. Centre de Recherche du Centre Hospitalier, Université de Sherbrooke, QC, Canada

11. Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley

12. Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

13. Department of Infection Epidemiology and Modeling, Norwegian Institute of Public Health, Oslo, Norway

14. Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA

15. Telethon Kids Institute, University of Western Australia, Crawley, WA 6009, Australia

16. National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA

17. Department of Pulmonology, GRIAC Research Institute,

18. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

19. Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Sorbonne Université, UPMC Univ Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health, Saint-Antoine Medical School, Paris, France

20. Department of Biological Sciences

21. Center for Human Health and the Environment, North Carolina State University, NC, USA

22. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA

23. University of California San Francisco, CA, USA

24. HDF Comprehensive Cancer Center, University of California, San Francisco, CA, USA

25. Computational Biology Core

26. Human Development & Health, Faculty of Medicine, University of Southampton, UK

27. Epigenetics Group, International Agency for Research on Cancer, Lyon, France

28. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

29. Department of Epidemiology, School of Public Health, University of Michigan, MI, USA

30. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands,

31. Division of Epidemiology, Biostatistics, and Environmental Health Sciences, School of Public Health, University of Memphis, Memphis, TN, USA

32. Department of Non-Communicable Disease, Norwegian Institute of Public Health, Oslo, Norway

33. Department of Global Public Health and Primary Care, University of Bergen, Norway

34. Medical Birth Registry of Norway, Norwegian Institute of Public Health, Bergen, Norway

35. The Curtin UWA Centre for Genetic Origins of Health and Disease, Faculty of Health Sciences, Curtin University Health Sciences, Curtin University and Faculty of Medicine Dentistry & Health Sciences, The University of Western Australia, Perth, Australia

36. Faculty of Medicine Dentistry & Health Sciences, The University of Western Australia, Perth, Australia

37. Department of Epidemiology, University of Groningen, University Medical Center Groningen, GRIAC Research Institute Groningen, The Netherlands

38. Research Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark

39. Department of Biological & Biomedical Sciences, North Carolina Central University, Durham, NC, USA

40. Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, USA

41. CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain

42. Department of Epidemiology and Biostatistics, University of California San Francisco, CA, USA

43. School of Public Health, University of California Berkeley, CA, USA

44. Division of Research, Kaiser Permanente Northern California, CA, UDA

45. Department of Medicine, Université de Sherbrooke, QC, Canada

46. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA

47. Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA

48. Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA

49. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands

50. Epidemiology and Biostatistics Department, University of South Carolina (Columbia), SC, USA

51. Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain

52. Domain of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway

53. Center for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden

54. Department of Public Health, School of Medicine, University of California, Davis, CA, USA

55. AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, USA

56. Department of Biochemistry, Université de Sherbrooke, QC, Canada

57. ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, QC, Canada

58. Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA

59. Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA

60. Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA

61. Sachs’ Children’s Hospital, South General Hospital, Stockholm, Sweden

62. Department of Pediatric and Adolescent Medicine, Oslo University Hospital, Norway

63. Norwegian Institute of Public Health, Oslo Norway

64. Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK

65. NIHR Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, UK

66. The David Hide Asthma and Allergy Research Centre, Isle of Wight, UK

67. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA

68. Novo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

69. Department of Clinical Epidemiology, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark

70. Department of Paediatric Pulmonology and Paediatric Allergy, University of Groningen, University Medical Center Groningen, Beatrix Children’s Hospital, GRIAC Research Institute, Groningen, the Netherlands

71. School of Women's and Infants' Health, The University of Western Australia, Crawley, WA 6009, Australia

Funder

Open Access Library Services at the University of Bristol

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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