P1 and P2' site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitor
Author:
Publisher
Oxford University Press (OUP)
Subject
Molecular Biology,Biochemistry,General Medicine
Link
http://academic.oup.com/jb/article-pdf/153/2/221/2459936/mvs133.pdf
Reference48 articles.
1. Regulation of coagulation by a multivalent Kunitz-type inhibitor
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4. Factor XI Activation in a Revised Model of Blood Coagulation
5. Factor XI contributes to thrombin generation in the absence of factor XII
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1. Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis;Bioorganic Chemistry;2024-01
2. Selection and in vitro and in vivo characterization of a Kunitz protease inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin;Journal of Biotechnology;2021-03
3. Structural studies of plasmin inhibition;Biochemical Society Transactions;2019-03-05
4. Two variants of the major serine protease inhibitor from the sea anemone Stichodactyla helianthus, expressed in Pichia pastoris;Protein Expression and Purification;2016-07
5. In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus;PLOS NEGLECT TROP D;2016
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