1. National Heart and Lung Institute, Imperial College London , London W12 0HS , UK
2. Imperial College Healthcare NHS Trust, Hammersmith Hospital , London W12 0HS , UK
3. Essex Cardiothoracic Centre, MSE Trust , Basildon, Essex , UK
4. MTRC, Anglia Ruskin School of Medicine , Chelmsford, Essex , UK
5. Barts Heart Centre, Barts Health NHS Trust , W Smithfield, London EC1A 7BE , UK
6. William Harvey Research Institute, Queen Mary University of London , London , UK
7. Department of Biostatistics, Vanderbilt University School of Medicine , Nashville, TN , USA