Peptide–Oleate Complexes Create Novel Membrane-Bound Compartments

Author:

Hansen Jesper S12,Tran Tuan Hiep1,Cavalera Michele1,Paul Sanchari1,Chaudhuri Arunima1,Lindkvist-Petersson Karin2,Ho James C S13,Svanborg Catharina1

Affiliation:

1. Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

2. Experimental Medical Science, Medical Structural Biology, Lund University, Lund, Sweden

3. Centre for Biomimetic Sensor Science, School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore

Abstract

AbstractA challenging question in evolutionary theory is the origin of cell division and plausible molecular mechanisms involved. Here, we made the surprising observation that complexes formed by short alpha-helical peptides and oleic acid can create multiple membrane-enclosed spaces from a single lipid vesicle. The findings suggest that such complexes may contain the molecular information necessary to initiate and sustain this process. Based on these observations, we propose a new molecular model to understand protocell division.

Funder

Swedish Cancer Society

Medical Research Council

Swedish Research Council

European Union's Horizon 2020 research and innovation programme

Hamlet-BC

Faculty of Lund University

Söderberg Foundation

Maggie Stephens Foundation

Österlund Foundation

Inga-Britt and Arne Lundberg Foundation

H.J. Forssman Foundation for Medical Research and Royal Physiographic Society

Hamlet Pharma to Lund University

Publisher

Oxford University Press (OUP)

Subject

Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics

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