Pneumococcal Capsule Synthesis Locus cps as Evolutionary Hotspot with Potential to Generate Novel Serotypes by Recombination

Author:

Mostowy Rafał J.1,Croucher Nicholas J.1,De Maio Nicola23,Chewapreecha Claire45,Salter Susannah J.6,Turner Paul78,Aanensen David M.19,Bentley Stephen D.6,Didelot Xavier1,Fraser Christophe110

Affiliation:

1. Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom

2. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

3. Institute for Emerging Infections, Oxford Martin School, Oxford, United Kingdom

4. Department of Medicine, University of Cambridge, Cambridge, United Kingdom

5. Bioinformatics and Systems Biology Program, School of Bioresources and Technology, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand

6. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

7. Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

8. Cambodia-Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia

9. Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom

10. Nuffield Department of Medicine, Li Ka Shing Centre for Health Information and Discovery, Oxford Big Data Institute, University of Oxford, Oxford, United Kingdom

Funder

National Institutes of Health

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics

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