Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China

Author:

Cai Yudong1,Fu Weiwei1,Cai Dawei2,Heller Rasmus3,Zheng Zhuqing1,Wen Jia1,Li Hui14,Wang Xiaolong1,Alshawi Akil56,Sun Zhouyong7,Zhu Siqi2,Wang Juan8,Yang Miaomiao7,Hu Songmei7,Li Yan1,Yang Zhirui1,Gong Mian1,Hou Yunan1,Lan Tianming910,Wu Kui1112,Chen Yulin1,Jiang Yu1,Wang Xihong1

Affiliation:

1. Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China

2. Research Center for Chinese Frontier Archaeology, Jilin University, Changchun, China

3. Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark

4. State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China

5. School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom

6. Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Baghdad, Iraqi Ministry of Higher Education and Scientific Research, Iraq

7. Shaanxi Academy of Archaeology, Xi’an, China

8. Henan Provincial Institute of Cultural Heritage and Archaeology, Zhengzhou, China

9. BGI-Shenzhen, Build 11, Beishan Industrial Zone, Yantian District, Shenzhen, China

10. Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark

11. China National GeneBank-Shenzhen, BGI-Shenzhen, China

12. Cancer Institute, BGI-Research, BGI-Shenzhen, Shenzhen, China

Abstract

Abstract Goats are one of the most widespread farmed animals across the world; however, their migration route to East Asia and local evolutionary history remain poorly understood. Here, we sequenced 27 ancient Chinese goat genomes dating from the Late Neolithic period to the Iron Age. We found close genetic affinities between ancient and modern Chinese goats, demonstrating their genetic continuity. We found that Chinese goats originated from the eastern regions around the Fertile Crescent, and we estimated that the ancestors of Chinese goats diverged from this population in the Chalcolithic period. Modern Chinese goats were divided into a northern and a southern group, coinciding with the most prominent climatic division in China, and two genes related to hair follicle development, FGF5 and EDA2R, were highly divergent between these populations. We identified a likely causal de novo deletion near FGF5 in northern Chinese goats that increased to high frequency over time, whereas EDA2R harbored standing variation dating to the Neolithic. Our findings add to our understanding of the genetic composition and local evolutionary process of Chinese goats.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

National Social Science Foundation of China

Villum Foundation Young Investigator

Northwest A&F University

NWAFU

Publisher

Oxford University Press (OUP)

Subject

Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics

Reference51 articles.

1. Convergent genomic signatures of domestication in sheep and goats;Alberto;Nat Commun,2018

2. The influence of physical conditions in the genesis of species;Allen;Radic Rev,1877

3. Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome;Bickhart;Nat Genet,2017

4. Edar signaling in the control of hair follicle development;Botchkarev;J Investig Dermatol Symp Proc,2005

5. The UCSC Genome Browser database: 2018 update;Casper;Nucleic Acids Res,2018

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3