Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals
Author:
Ågren Richard1, Patil Snehal2, Zhou Xiang2, Palotie Aarno, Daly Mark, Riley-Gills Bridget, Jacob Howard, Paul Dirk, Matakidou Athena, Platt Adam, Runz Heiko, John Sally, Okafo George, Lawless Nathan, Plenge Robert, Maranville Joseph, McCarthy Mark, Hunkapiller Julie, Ehm Margaret G, Auro Kirsi, Longerich Simonne, Fox Caroline, Mälarstig Anders, Klinger Katherine, Raipal Deepak, Green Eric, Graham Robert, Yang Robert, ÓDonnell Chris, Mäkelä Tomi, Kaprio Jaakko, Virolainen Petri, Hakanen Antti, Kilpi Terhi, Perola Markus, Partanen Jukka, Pitkäranta Anne, Junttila Juhani, Serpi Raisa, Laitinen Tarja, Kosma Veli-Matti, Laukkanen Jari, Hautalahti Marco, Tuovila Outi, Pakkanen Raimo, Waring Jeffrey, Riley-Gillis Bridget, Rahimov Fedik, Tachmazidou Ioanna, Chen Chia-Yen, Runz Heiko, Ding Zhihao, Jung Marc, Biswas Shameek, Pendergrass Rion, Hunkapiller Julie, Ehm Margaret G, Pulford David, Raghavan Neha, Huertas-Vazquez Adriana, Sul Jae-Hoon, Mälarstig Anders, Hu Xinli, Klinger Katherine, Graham Robert, Green Eric, Mozaffari Sahar, Waterworth Dawn, Renaud Nicole, Obeidat Máen, Ripatti Samuli, Schleutker Johanna, Perola Markus, Arvas Mikko, Carpén Olli, Hinttala Reetta, Kettunen Johannes, Mannermaa Arto, Aalto-Setälä Katriina, Kähönen Mika, Laukkanen Jari, Mäkelä Johanna, Kälviäinen Reetta, Julkunen Valtteri, Soininen Hilkka, Remes Anne, Hiltunen Mikko, Peltola Jukka, Raivio Minna, Tienari Pentti, Rinne Juha, Kallionpää Roosa, Partanen Juulia, Abbasi Ali, Ziemann Adam, Smaoui Nizar, Lehtonen Anne, Eaton Susan, Runz Heiko, Lahdenperä Sanni, Biswas Shameek, Hunkapiller Julie, Bowers Natalie, Teng Edmond, Pendergrass Rion, Xu Fanli, Pulford David, Auro Kirsi, Addis Laura, Eicher John, Li Qingqin S, He Karen, Khramtsova Ekaterina, Raghavan Neha, Färkkilä Martti, Koskela Jukka, Pikkarainen Sampsa, Jussila Airi, Kaukinen Katri, Blomster Timo, Kiviniemi Mikko, Voutilainen Markku, Daly Mark, Abbasi Ali, Waring Jeffrey, Smaoui Nizar, Rahimov Fedik, Lehtonen Anne, Lu Tim, Bowers Natalie, Pendergrass Rion, McCarthy Linda, Hart Amy, Guan Meijian, Miller Jason, Kalpala Kirsi, Miller Melissa, Hu Xinli, Eklund Kari, Palomäki Antti, Isomäki Pia, Pirilä Laura, Kaipiainen-Seppänen Oili, Huhtakangas Johanna, Mars Nina, Abbasi Ali, Waring Jeffrey, Rahimov Fedik, Lertratanakul Apinya, Smaoui Nizar, Lehtonen Anne, Close David, Hochfeld Marla, Bowers Natalie, Pendergrass Rion, Gordillo Jorge Esparza, Auro Kirsi, Waterworth Dawn, Farias Fabiana, Kalpala Kirsi, Bing Nan, Hu Xinli, Laitinen Tarja, Pelkonen Margit, Kauppi Paula, Kankaanranta Hannu, Harju Terttu, Lahesmaa Riitta, Smaoui Nizar, Mackay Alex, Lassi Glenda, Eaton Susan, Chen Hubert, Pendergrass Rion, Bowers Natalie, Betts Joanna, Auro Kirsi, Mishra Rajashree, Mouded Majd, Ngo Debby, Niiranen Teemu, Vaura Felix, Salomaa Veikko, Metsärinne Kaj, Aittokallio Jenni, Kähönen Mika, Hernesniemi Jussi, Gordin Daniel, Sinisalo Juha, Taskinen Marja-Riitta, Tuomi Tiinamaija, Hiltunen Timo, Laukkanen Jari, Elliott Amanda, Reeve Mary Pat, Ruotsalainen Sanni, Challis Benjamin, Paul Dirk, Hunkapiller Julie, Bowers Natalie, Pendergrass Rion, Chu Audrey, Auro Kirsi, Reilly Dermot, Mendelson Mike, Parkkinen Jaakko, Miller Melissa, Meretoja Tuomo, Joensuu Heikki, Carpén Olli, Mattson Johanna, Salminen Eveliina, Auranen Annika, Karihtala Peeter, Auvinen Päivi, Elenius Klaus, Schleutker Johanna, Pitkänen Esa, Mars Nina, Daly Mark, Popovic Relja, Waring Jeffrey, Riley-Gillis Bridget, Lehtonen Anne, Schutzman Jennifer, Hunkapiller Julie, Bowers Natalie, Pendergrass Rion, Kulkarni Diptee, Auro Kirsi, Porello Alessandro, Loboda Andrey, Lehtonen Heli, McDonough Stefan, Vuoti Sauli, Kaarniranta Kai, Turunen Joni A, Ollila Terhi, Uusitalo Hannu, Karjalainen Juha, Pitkänen Esa, Liu Mengzhen, Runz Heiko, Loomis Stephanie, Strauss Erich, Bowers Natalie, Chen Hao, Pendergrass Rion, Tasanen Kaisa, Huilaja Laura, Hannula-Jouppi Katariina, Salmi Teea, Peltonen Sirkku, Koulu Leena, Smaoui Nizar, Rahimov Fedik, Lehtonen Anne, Choy David, Pendergrass Rion, Waterworth Dawn, Kalpala Kirsi, Wu Ying, Pussinen Pirkko, Salminen Aino, Salo Tuula, Rice David, Nieminen Pekka, Palotie Ulla, Siponen Maria, Suominen Liisa, Mäntylä Päivi, Gursoy Ulvi, Anttonen Vuokko, Sipilä Kirsi, Pendergrass Rion, Laivuori Hannele, Kurra Venla, Kotaniemi-Talonen Laura, Heikinheimo Oskari, Kalliala Ilkka, Aaltonen Lauri, Jokimaa Varpu, Kettunen Johannes, Vääräsmäki Marja, Uimari Outi, Morin-Papunen Laure, Niinimäki Maarit, Piltonen Terhi, Kivinen Katja, Widen Elisabeth, Tukiainen Taru, Reeve Mary Pat, Daly Mark, Välimäki Niko, Laakkonen Eija, Tyrmi Jaakko, Silven Heidi, Sliz Eeva, Arffman Riikka, Savukoski Susanna, Laisk Triin, Pujol Natalia, Liu Mengzhen, Riley-Gillis Bridget, Pendergrass Rion, Kumar Janet, Auro Kirsi, Hovatta Iiris, Chen Chia-Yen, Isometsä Erkki, Veerapen Kumar, Ollila Hanna, Suvisaari Jaana, Als Thomas Damm, Mäkitie Antti, Bizaki-Vallaskangas Argyro, Toppila-Salmi Sanna, Willberg Tytti, Saarentaus Elmo, Aarnisalo Antti, Salminen Eveliina, Rahikkala Elisa, Kettunen Johannes, Aittomäki Kristiina, Åberg Fredrik, Kurki Mitja, Ripatti Samuli, Daly Mark, Karjalainen Juha, Havulinna Aki, Mehtonen Juha, Palta Priit, Hassan Shabbeer, Parolo Pietro Della Briotta, Zhou Wei, Maasha Mutaamba, Veerapen Kumar, Hassan Shabbeer, Lemmelä Susanna, Rivas Manuel, Niemi Mari E, Palotie Aarno, Liu Aoxing, Lehisto Arto, Ganna Andrea, Llorens Vincent, Laivuori Hannele, Tukiainen Taru, Reeve Mary Pat, Heyne Henrike, Mars Nina, Rämö Joel, Saarentaus Elmo, Ollila Hanna, Rodosthenous Rodos, Strausz Satu, Palotie Tuula, Palin Kimmo, Garcia-Tabuenca Javier, Siirtola Harri, Kiiskinen Tuomo, Lee Jiwoo, Tsuo Kristin, Elliott Amanda, Kristiansson Kati, Arvas Mikko, Hyvärinen Kati, Ritari Jarmo, Carpén Olli, Kettunen Johannes, Pylkäs Katri, Sliz Eeva, Karjalainen Minna, Mantere Tuomo, Kangasniemi Eeva, Heikkinen Sami, Mannermaa Arto, Laakkonen Eija, Pitkänen Nina, Lessard Samuel, Chatelain Clément, Terho Perttu, Soini Sirpa, Partanen Jukka, Punkka Eero, Serpi Raisa, Siltanen Sanna, Kosma Veli-Matti, Kuopio Teijo, Jalanko Anu, Shen Huei-Yi, Kajanne Risto, Aavikko Mervi, Kurki Mitja, Karjalainen Juha, Parolo Pietro Della Briotta, Lehisto Arto, Mehtonen Juha, Zhou Wei, Kanai Masahiro, Maasha Mutaamba, Veerapen Kumar, Laivuori Hannele, Havulinna Aki, Lemmelä Susanna, Kiiskinen Tuomo, Lahtela L Elisa, Kaunisto Mari, Kilpeläinen Elina, Sipilä Timo P, Dada Oluwaseun Alexander, Ghazal Awaisa, Kytölä Anastasia, Weldatsadik Rigbe, Donner Kati, Sipilä Timo P, Loukola Anu, Laiho Päivi, Sistonen Tuuli, Kaiharju Essi, Laukkanen Markku, Järvensivu Elina, Lähteenmäki Sini, Männikkö Lotta, Wong Regis, Toivola Auli, Brunfeldt Minna, Mattsson Hannele, Kristiansson Kati, Lemmelä Susanna, Koskelainen Sami, Hiekkalinna Tero, Paajanen Teemu, Palta Priit, Pärn Kalle, Kals Mart, Luo Shuang, Sinha Vishal, Laitinen Tarja, Reeve Mary Pat, Niemi Marianna, Veerapen Kumar, Siirtola Harri, Gracia-Tabuenca Javier, Helminen Mika, Luukkaala Tiina, Vähätalo Iida, Pitkänen Jyrki, Hautalahti Marco, Mäkelä Johanna, Smith Sarah, Southerington Tom, Sahlholm Kristoffer13, Pääbo Svante45, Zeberg Hugo145ORCID,
Affiliation:
1. Department of Physiology and Pharmacology, Karolinska Institutet , Stockholm , Sweden 2. Department of Biostatistics, University of Michigan , Ann Arbor, MI , USA 3. Department of Integrative Medical Biology, Wallenberg Centre for Molecular Medicine, Umeå University , Umeå , Sweden 4. Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology , Leipzig , Germany 5. Human Evolutionary Genomics Unit, Okinawa Institute of Science and Technology , Okinawa , Japan
Abstract
Abstract
Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in northern Europe. Here, we meta-analyze 3 biobanks comprising 7,871 cases and 645,880 controls and find 61 genome-wide significant variants associated with Dupuytren's disease. We show that 3 of the 61 loci harbor alleles of Neandertal origin, including the second and third most strongly associated ones (P = 6.4 × 10−132 and P = 9.2 × 10−69, respectively). For the most strongly associated Neandertal variant, we identify EPDR1 as the causal gene. Dupuytren's disease is an example of how admixture with Neandertals has shaped regional differences in disease prevalence.
Publisher
Oxford University Press (OUP)
Subject
Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics
Cited by
4 articles.
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