Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

Author:

Tapias Victor1ORCID,Jainuddin Shari1,Ahuja Manuj2,Stack Cliona1,Elipenahli Ceyhan1,Vignisse Julie3,Gerges Meri1,Starkova Natalia1,Xu Hui1,Starkov Anatoly A1,Bettendorff Lucien3,Hushpulian Dmitry M45,Smirnova Natalya A4,Gazaryan Irina G67,Kaidery Navneet A2,Wakade Sushama2,Calingasan Noel Y1,Thomas Bobby2,Gibson Gary E18,Dumont Magali1,Beal M Flint1

Affiliation:

1. Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA

2. Department of Pharmacology, Toxicology and Neurology, Augusta University, Augusta, GA 30912, USA

3. Laboratory of Neurophysiology, GIGA-Neurosciences, University of Liege, 4000 Liege, Belgium

4. D. Rogachev Federal Scientific and Clinical Center for Pediatric Hematology, Oncology, and Immunology, 117997 Moscow, Russia

5. Veropharm, Abbott EPD, 115088 Moscow, Russia

6. Department of Chemistry and Physical Sciences, Pace University, Pleasantville, NY 10570, USA

7. Department of Enzymology, School of Chemistry, 119991 Moscow, Russia

8. Burke Medical Research Institute, Weill Cornell Medicine, White Plains, NY 10605, USA

Funder

National Institute on Aging

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

Reference94 articles.

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2. Thiamine homeostasis in neuroblastoma cells;Bettendorff;Neurochem. Int,1995

3. Thiamine, thiamine phosphates, and their metabolizing enzymes in human brain;Bettendorff;J. Neurochem,2002

4. Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells;Gangolf;PLoS One,2010

5. Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer’s disease;Gibson;Arch. Neurol,1988

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