Ulk2 controls cortical excitatory–inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons

Author:

Sumitomo Akiko1,Yukitake Hiroshi2,Hirai Kazuko1,Horike Kouta1,Ueta Keisho1,Chung Youjin2,Warabi Eiji3,Yanagawa Toru3,Kitaoka Shiho45,Furuyashiki Tomoyuki45,Narumiya Shuh4,Hirano Tomoo6,Niwa Minae2,Sibille Etienne7,Hikida Takatoshi1,Sakurai Takeshi1,Ishizuka Koko2,Sawa Akira2,Tomoda Toshifumi17

Affiliation:

1. Department of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan

2. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

3. Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan

4. CREST Project, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan

5. Department of Pharmacology, Kobe University Graduate School of Medicine, Hyogo, Japan

6. Department of Biophysics, Kyoto University Graduate School of Science, Kyoto, Japan

7. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada

Funder

Naito Foundation

Maryland Stem Cell Research Fund

Childrends Tumor Foundation-Drug Discovery Initiative

National Alliance for Research on Schizophrenia and Depression

National Institute of Mental Health

Kato Memorial Trust for Nambyo Research

Takeda Science Foundation

Stanley Foundation

Japan Society of Promotion of Science

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

Reference37 articles.

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2. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice;Hara;Nature,2006

3. Loss of autophagy in the central nervous system causes neurodegeneration in mice;Komatsu;Nature,2006

4. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration;Komatsu;Proc. Natl. Acad. Sci. U.S.A,2007

5. UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly;Toda;Genes Dev,2008

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