In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson’s disease-Reference-Cited by-同舟云学术

In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson’s disease

Published:2018-08-22 Issue: Volume: Page:
ISSN:0964-6906
Container-title:Human Molecular Genetics
language:en
Short-container-title:

Author:

Uenaka Takeshi¹,Satake Wataru¹,Cha Pei-Chieng¹,Hayakawa Hideki²,Baba Kousuke²,Jiang Shiying²,Kobayashi Kazuhiro¹,Kanagawa Motoi¹,Okada Yukinori³⁴,Mochizuki Hideki²,Toda Tatsushi¹⁵

Affiliation:

1. Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan

2. Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan

3. Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan

4. Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Osaka 565-0871, Japan

5. Department of Neurology, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo 113-8655, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Brain Mapping by Integrated Neurotechnologies for Disease Studies

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

Link

http://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddy279/25525658/ddy279.pdf

Reference65 articles.

1. Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease;Volta;Lancet Neurol.,2015

2. Discovery and preclinical validation of drug indications using compendia of public gene expression data;Sirota;Sci. Transl. Med.,2011

3. Validating therapeutic targets through human genetics;Plenge;Nat. Rev. Drug Dis.,2013

4. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease;Satake;Nat. Genet.,2009

5. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene database;Lill;PLoS Genet.,2012

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets;Frontiers in Cellular Neuroscience;2024-01-19

2. Analyzing ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets;2023-11-17

3. The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology;npj Parkinson's Disease;2023-03-27

4. Necroptosis in CNS diseases: Focus on astrocytes;Frontiers in Aging Neuroscience;2023-01-27

5. Oncogenic BRAF^V600E induces microglial proliferation through extracellular signal-regulated kinase and neuronal death through c-Jun N-terminal kinase;Neural Regeneration Research;2023