A γ‐secretase inhibitor blocks Notch signalingin vivoand causes a severe neurogenic phenotype in zebrafish-Reference-Cited by-同舟云学术

A γ‐secretase inhibitor blocks Notch signalingin vivoand causes a severe neurogenic phenotype in zebrafish

Published:2002-07 Issue:7 Volume:3 Page:688-694
ISSN:1469-221X
Container-title:EMBO reports
language:en
Short-container-title:EMBO Rep

Author:

Geling Andrea¹²,Steiner Harald³,Willem Michael³,Bally‐Cuif Laure¹²,Haass Christian³

Affiliation:

1. Zebrafish Neurogenetics Junior Research Group, Institute for Virology, Technical University Munich Trogerstrasse 4b D‐81675 Munich Germany

2. GSF‐National Research Center for Environment and Health, Institute of Mammalian Genetics Ingolstaedter Landstrasse 1 D‐85764 Neuherberg Germany

3. Adolf Butenandt Institute, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig Maximilians University Munich, Department of Biochemistry Schillerstrasse 44 D‐80336 Munich Germany

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1093/embo-reports/kvf124

Reference56 articles.

1. Notch Is Expressed in Adult Brain, Is Coexpressed with Presenilin-1, and Is Altered in Alzheimer Disease

2. Aspartate Mutations in Presenilin and γ-Secretase Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with Relative Preservation of Notch1 Signaling

3. Zebrafish developmental genetics and central nervous system development

4. The activity of neurogenin1 is controlled by local cues in the zebrafish embryo;Blader P.;Development,1997

5. The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

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