Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures

Author:

Mahdally Sarah M1,Izquierdo Mariana2,Viscardi Rose M1,Magder Laurence S3,Crowley Helena M4,Bafford Andrea C5,Drachenberg Cinthia B6,Farfan Mauricio J7,Fasano Alessio8,Sztein Marcelo B2,Salerno-Goncalves Rosangela2ORCID

Affiliation:

1. Division of Neonatology, Department of Pediatrics, University of Maryland School of Medicine , Baltimore, MD , USA

2. Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, MD , USA

3. Department of Epidemiology and Public Health, University of Maryland School of Medicine , Baltimore, MD , USA

4. Division of Pediatric Surgery and Urology, University of Maryland School of Medicine , Baltimore, MD , USA

5. Division of General and Oncologic Surgery, University of Maryland School of Medicine , Baltimore, MD , USA

6. Department of Pathology, University of Maryland School of Medicine , Baltimore, MD , USA

7. Departamento de Pediatría y Cirugía Infantil, Facultad de Medicina, Hospital Dr. Luis Calvo Mackenna, Universidad de Chile , Santiago , Chile

8. Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children , Boston, MA , USA

Abstract

Abstract Previous work has shown that Secretory-IgA (SIgA) binding to the intestinal microbiota is variable and may regulate host inflammatory bowel responses. Nevertheless, the impact of the SIgA functional binding to the microbiota remains largely unknown in preterm infants whose immature epithelial barriers make them particularly susceptible to inflammation. Here, we investigated SIgA binding to intestinal microbiota isolated from stools of preterm infants <33 weeks gestation with various levels of intestinal permeability. We found that SIgA binding to intestinal microbiota attenuates inflammatory reactions in preterm infants. We also observed a significant correlation between SIgA affinity to the microbiota and the infant’s intestinal barrier maturation. Still, SIgA affinity was not associated with developing host defenses, such as the production of mucus and inflammatory calprotectin protein, but it depended on the microbiota shifts as the intestinal barrier matures. In conclusion, we reported an association between the SIgA functional binding to the microbiota and the maturity of the preterm infant’s intestinal barrier, indicating that the pattern of SIgA coating is altered as the intestinal barrier matures.

Funder

Cooperative Center for Human Immunology—CCHI

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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