Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae-Reference-Cited by-同舟云学术

Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae

Published:2021-06-13 Issue:9 Volume:76 Page:2302-2305
ISSN:0305-7453
Container-title:Journal of Antimicrobial Chemotherapy
language:en
Short-container-title:

Author:

Hu Yanmin¹^ORCID,Coates Anthony¹²

Affiliation:

1. Institute for Infection and Immunity, St George’s University of London, London, UK

2. Helperby Therapeutics Group plc, London, UK

Abstract

Abstract Objectives To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae. Methods MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time–kill analysis. Results We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time–kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem. Conclusions Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro.

Funder

Helperby Therapeutics Group Ltd

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

Link

https://academic.oup.com/jac/article-pdf/76/9/2302/41685445/dkab184.pdf

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