Factors Influencing the Incubation of an Infectious Form of Creutzfeldt-Jakob Disease-Reference-Cited by-同舟云学术

Factors Influencing the Incubation of an Infectious Form of Creutzfeldt-Jakob Disease

Published:2019-07-28 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Peckeu Laurène¹,Brandel Jean-Philippe¹²,Welaratne Arlette¹²,Amar Elodie³,Costagliola Dominique⁴,Haïk Stéphane¹²⁵

Affiliation:

1. Sorbonne Université, INSERM, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, ICM

2. AP-HP, Cellule Nationale de Référence des maladies de Creutzfeldt-Jakob, Groupe Hospitalier Pitié-Salpêtrière

3. AP-HP, Hôpital Lariboisière, Service de Biochimie et Biologie Moléculaire, Université Paris Descartes, Paris, France

4. Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique

5. AP-HP, Hôpital de la Pitié-Salpêtrière, Laboratoire de Neuropathologie R Escourolle

Abstract

Abstract The French epidemics of iatrogenic Creutzfeldt-Jakob disease after growth hormone (GH) treatment provide an opportunity to understand factors governing the inter-human transmission of prions. The present analysis relying on truncated Weibull distribution supports a relationship between host genetics, dose of the at-risk GH, age at treatment onset, and duration of the incubation period.

Funder

Investissements d’avenir

Santé Publique France

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciz692/30011867/ciz692.pdf

Reference12 articles.

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2. Creutzfeldt-Jakob disease in pituitary growth hormone recipients in the United States;Fradkin;JAMA,1991