Clinical, histopathological and ultrastructural features of human monkeypox infection in the 2022 outbreak: report of a case with immunohistochemistry for vaccinia virus

Author:

Prieto-Pérez L1ORCID,Vicente Montaña A M2,Santonja C1,Fortes J1,García-Fresnadillo D3,Jo-Velasco M1,Requena L1,Cabello A1ORCID,Fernández-Roblas R1,Álvarez B1,Carrillo I1,Górgolas M1

Affiliation:

1. University Hospital Fundación Jiménez Díaz , Madrid , Spain

2. ICTS-National Centre of Electron Microscopy, Complutense University of Madrid , Spain

3. University Hospital Puerta de Hierro , Majadahonda; Madrid , Spain

Abstract

We provide a full description of the clinical, histopathological, immunohistochemical and ultrastructural features of the current human monkeypox virus. A skin snip was obtained in a HIV-infected patient in the wake of the monkeypox outbreak in Spain. Immunohistochemistry was strongly positive for anti-vaccinia virus. Under electron microscopy, mature viruses and virions were clearly visible.

Publisher

Oxford University Press (OUP)

Subject

Dermatology

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