Diffuse cutaneous melanosis is an under-recognized sign with a poor prognosis in patients with melanoma

Author:

Coe James1ORCID,Smith Hayley1,Edward Sara2,Dunwoodie Elaine3,Hook Jane3,Marples Maria3,Mitra Angana1

Affiliation:

1. Leeds Centre for Dermatology and Leeds Teaching Hospitals, National Health Service (NHS) Trust , Leeds , UK

2. Department of Histopathology, Leeds Teaching Hospitals, National Health Service (NHS) Trust , Leeds , UK

3. Department of Medical Oncology, Leeds Cancer Centre, St James’s University Hospital, Leeds Teaching Hospitals , Leeds , UK

Abstract

We report the largest single-centre case series of diffuse cutaneous melanosis in the literature. This is a rare clinical presentation seen in patients with malignant melanoma that is important to recognize as it may be the first sign of distant metastases and has a very poor prognosis.

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Reference3 articles.

1. [Case of a combination of a pigment cancer with a pure pigment tumour];Wagner;Arch Heilkunde,1864

2. Diffuse melanosis cutis: a systematic review of the literature;Sebaratnam;J Am Acad Dermatol,2013

3. Diffuse melanosis after chemotherapy-induced tumour lysis syndrome in a patient with metastatic melanoma;Busam;J Cutan Pathol,2004

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