Dynamics of antibody response to BNT162b2 mRNA COVID-19 vaccine after 6 months

Author:

Ponticelli Domenico1,Antonazzo Ippazio C2,Caci Grazia3,Vitale Andrea1,Della Ragione Giovanni1,Romano Maria L1,Borrelli Mario1,Schiavone Beniamino1,Polosa Riccardo45,Ferrara Pietro26ORCID

Affiliation:

1. Pineta Grande Hospital, Castel Volturno (Caserta), Italy

2. Center for Public Health Research, University of Milan—Bicocca, Monza, Italy

3. Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

4. Center of Excellence for the Acceleration of HArm Reduction (CoEHAR), University of Catania, Catania, Italy

5. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

6. IRCCS MultiMedica, Sesto San Giovanni (Milan), Italy

Abstract

This sero-survey describes the level and time-trend of antibodies elicited by BNT162b2 COVID-19 vaccine up to 6 months. A strong seroconversion was seen at 30-day serology, with persistence of anti-SARS-CoV-2 S-RBD IgG through 6 months from vaccination. However, the level of vaccine-induced antibodies started to decrease from the second month.

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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