Did Zika virus attenuation or increased virulence lead to the emergence of congenital Zika syndrome?

Abstract

The global emergence of Zika revealed the unprecedented ability of a mosquito-borne virus to cause severe congenital abnormalities. Recent studies indicate that the ability to harm fetuses is not a novel feature of Zika virus. Counter-intuitively, it may have in fact recently ‘attenuated’ from killing embryos to causing birth defects.