Can melatonin be used as a potential antioxidant and sleep aid supplement for high-altitude travelers?

Abstract

Traveling to high-altitude destinations is associated with risks such as high-altitude sicknesses and impaired sleep and performance. Although antioxidant supplementation may be beneficial, conflicting study results impede clear clinical guidelines. Herein, we highlight the potential of the antioxidant compound melatonin that is surprisingly poorly investigated in high-altitude settings.