Improving the diagnosis and management of acute schistosomiasis with antibody, antigen and molecular techniques: lessons from a cluster of six travellers

Author:

Camprubí-Ferrer Daniel1,Romero Lucía1,Van Esbroeck Marjan2,Wammes Linda J3,Almuedo-Riera Alex1,Rodriguez-Valero Natalia1,Balerdi-Sarasola Leire1,Hoekstra Pytsje T4,Subirà Carme1,Valls Maria Eugenia5,Micalessi Isabel2,Corstjens Paul6,Cortes-Serra Nuria1,Huyse Tine7,Benegas Mariana8,Álvarez-Martínez Miriam J5,Muñoz Jose1,van Lieshout Lisette4

Affiliation:

1. ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona 08036, Spain

2. Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp 2000, Belgium

3. Department of Medical Microbiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands

4. Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands

5. Microbiology Department, Hospital Clínic Barcelona, Barcelona 08036, Spain

6. Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands

7. Department of Biology, Royal Museum for Central Africa, Tervuren 3080, Belgium

8. Radiology Department, Hospital Clínic Barcelona, Barcelona 08036, Spain

Abstract

Different diagnostic tests were evaluated in a cluster of six European travellers with acute schistosomiasis (AS) acquired in Mozambique. Adult worm and soluble egg antibodies, circulating anodic antigen (CAA) and DNA detection allowed early confirmation of AS. CAA permitted monitoring treatment response and Sm1-7 polymerase chain reaction allowed identification of Schistosoma mansoni complex.

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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