Affiliation:
1. Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London W12 0NN, UK
Abstract
Abstract
The generation of high-affinity long-lived antibody responses is dependent on the differentiation of plasma cells and memory B cells, which are themselves the product of the germinal centre (GC) response. The GC forms in secondary lymphoid organs in response to antigenic stimulation and is dependent on the coordinated interactions between many types of leucocytes. These leucocytes are brought together on an interconnected network of specialized lymphoid stromal cells, which provide physical and chemical guidance to immune cells that are essential for the GC response. In this review we will highlight recent advancements in lymphoid stromal cell immunobiology and their role in regulating the GC, and discuss the contribution of lymphoid stromal cells to age-associated immunosenescence.
Publisher
Oxford University Press (OUP)
Subject
General Earth and Planetary Sciences,General Environmental Science
Reference168 articles.
1. Patterns of lymphatic drainage in the adult laboratory rat;Tilney;J Anat,1971
2. Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex;Gretz;Immunol Rev,1997
3. Sophisticated strategies for information encounter in the lymph node: the reticular network as a conduit of soluble information and a highway for cell traffic;Gretz;J Immunol,1996
4. Overall architecture and pattern of lymph flow in the rat lymph node;Sainte-Marie;Am J Anat,1982
5. High endothelial venules and other blood vessels: critical regulators of lymphoid organ development and function;Ager;Front Immunol,2017
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