The role and uses of antibodies in COVID-19 infections: a living review
Author:
Scourfield D Oliver1, Reed Sophie G1, Quastel Max2, Alderson Jennifer3, Bart Valentina M T1, Teijeira Crespo Alicia4, Jones Ruth5, Pring Ellie1, Richter Felix Clemens3ORCID, Ahern David J, Almuttaqi Hannah, Alonzi Dominic S, Alrubayyi Aljawharah, Alsaleh Ghada, Bart Valentina M T, Batchelor Vicky, Bayliss Rebecca, Berthold Dorothée L, Bezbradica Jelena S, Bharuchq Tehmina, Borrmann Helene, Borsa Mariana, Borst Rowie, Brun Juliane, Burnell Stephanie E A, Capitani Lorenzo, Cavounidis Athena, Chapman Lucy, Chauveau Anne, Cifuentes Liliana, Codd Amy Susan, Compeer Ewoud Bernardus, Coveney Clarissa, Cross Amy, Danielli Sara, Davies Luke C, Dendrou Calliope A, Dimonte Sandra, Peter Durairaj Ruban Rex, Dustin Lynn B, Dyer Arthur, Fielding Ceri, Fischer Fabian, Gallimore Awen, Galloway Sarah, Gammage Anís, Gea-Mallorquí Ester, Godkin Andrew, Hanna Stephanie Jean, Heuberger Cornelia, Hulin-Curtis Sarah, Issa Fadi, Jones Emma, Jones Ruth, Ladell Kristin, Lauder Sarah N, Liddiard Kate, Ligoxygakis Petros, Lu Fangfang, MacLachlan Bruce, Maleki-Toyserkani Shayda, Mann Elizabeth H, Marzeda Anna M, James Matthews Reginald, Mazet Julie M, Milicic Anita, Mitchell Emma, Moon Owen, Nguyen Van Dien, O'Hanlon Miriam, Eléonore Pavillet Clara, Peppa Dimitra, Pires Ana, Pring Eleanor, Quastel Max, Reed Sophie, Rehwinkel Jan, Richmond Niamh, Richter Felix Clemens, Robinson Alice J B, Rodrigues Patrícia R S, Sabberwal Pragati, Sami Arvind, Peres Raphael Sanches, Sattentau Quentin, Schonfeldova Barbora, Scourfield David Oliver, Selvakumar Tharini A, Shepherd Freya R, Shorten Cariad, Simon Anna Katharina, Smith Adrian L, Crespo Alicia Teijeira, Tellier Michael, Thornton Emily, Uhl Lion F K, van Grinsven Erinke, Wann Angus K T, Williams Richard, Wilson Joseph D, Zhou Dingxi, Zhu Zihan, Burnell Stephanie E A1ORCID,
Affiliation:
1. Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK 2. Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK 3. Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, OX3 FTY, UK 4. Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, CF14 4XN UK 5. Dementia Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK
Abstract
Abstract
Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current pandemic. Characterizing humoral responses towards SARS-CoV-2, as well as closely related strains, will help determine whether antibodies are central to infection control, and aid the design of therapeutics and vaccine candidates. This review outlines the major aspects of SARS-CoV-2-specific antibody research to date, with a focus on the various prophylactic and therapeutic uses of antibodies to alleviate disease in addition to the potential of cross-reactive therapies and the implications of long-term immunity.
Publisher
Oxford University Press (OUP)
Subject
General Earth and Planetary Sciences,General Environmental Science
Cited by
20 articles.
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