1. Department of Systems Medicine, Keio University School of Medicine , Tokyo 160-8582 , Japan
2. Department of Molecular Biology, Yokohama City University, School of Medicine , Kanagawa 236-0027 , Japan
3. Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University , Kumamoto 860-0811 , Japan
4. Integrated Medical and Agricultural School of Public Health, Ehime University , Ehime 791-0295 , Japan
5. Division of Allergy & Immunology, Cincinnati Children’s Hospital Medical Center , Cincinnati, OH 45229-3026 , USA
6. Elixirgen Therapeutics, Inc. , Baltimore, MD 21205 , USA