1. Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, USA, 2Genome Center, Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA and 3Manoa BioSciences, Honolulu, HI 96819, USA