Affiliation:
1. Medical Union Pharmaceuticals Co, Methodology and Stability Section, Department of Research and Development, Abu-Sultan, Ismailia, Egypt
Abstract
Abstract
An isocratic, reversed-phase liquid chromatographic (LC) method was developed for simultaneous determination of pseudoephedrine hydrochloride (I) and carbinoxamine maleate (II) in a pharmaceutical dosage form. Analysis was conducted on a CN column (10μm), with a mobile phase consisting of acetonitrile-methanol-phosphate buffer (pH 5.3)-water (140 + 170 + 40 + 100) and at a detection wavelength of 262 nm. The method was validated for linearity, precision, system reproducibility, and accuracy. Recoveries at 80-120% of labeled claim ranged from 97.4 to 100.7% and from 98.5 to 100.2% for I and II, respectively. Results were linear (correlation coefficient, r > 0.9995 for I in the range 250-750 (μ/mL and r > 0.9999 for II in the range 20-60 μg/mL)
Publisher
Oxford University Press (OUP)
Subject
Pharmacology,Agronomy and Crop Science,Environmental Chemistry,Food Science,Analytical Chemistry
Cited by
8 articles.
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