Highly efficient genome editing via CRISPR–Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression

Author:

Li Xiao-Lan12,Li Guo-Hua12,Fu Juan34,Fu Ya-Wen12ORCID,Zhang Lu12,Chen Wanqiu5,Arakaki Cameron5,Zhang Jian-Ping126,Wen Wei12,Zhao Mei12,Chen Weisheng V7,Botimer Gary D8,Baylink David5,Aranda Leslie5,Choi Hannah5,Bechar Rachel9,Talbot Prue9,Sun Chang-Kai31011,Cheng Tao12101213,Zhang Xiao-Bing1251213

Affiliation:

1. State Key Laboratory of Experimental Hematology, Tianjin 300020, China

2. Institute of Hematology and Blood Disease Hospital, Tianjin 300020, China

3. Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University, Dalian 116044, China

4. Department of Obstetrics and Gynecology, the First Affiliated Hospital of Dalian Medical University, Dalian 116044, China

5. Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA

6. CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin 300020, China

7. Leveragen, Inc., Cambridge, MA 01605, USA

8. Department of Orthopaedic Surgery, Loma Linda University, Loma Linda, CA 92350, USA

9. UCR Stem Cell Center and Core, University of California at Riverside, Riverside, CA 92521, USA

10. Research & Educational Center for the Control Engineering of Translational Precision Medicine (R-ECCE-TPM), School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China

11. State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China

12. Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin 300020, China

13. Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China

Funder

Ministry of Science and Technology of China

National Natural Science Foundation of China

Chinese Academy of Medical Sciences

CAMS Key Laboratory of Gene Therapy for Blood Diseases

Fundamental Research Funds for Central Universities

State Key Laboratory of Bioelectronics, Southeast University

Loma Linda University

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference87 articles.

1. Embryonic stem cell lines derived from human blastocysts;Thomson;Science,1998

2. Induced pluripotent stem cell lines derived from human somatic cells;Yu;Science,2007

3. Induction of pluripotent stem cells from adult human fibroblasts by defined factors;Takahashi;Cell,2007

4. Cellular reprogramming of human peripheral blood cells;Zhang;Genomics Proteomics Bioinformatics,2013

5. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells;Thomas;Cell,1987

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