Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets

Author:

Lampe Johanna W.,King Irena B.,Li Sue,Grate Margaret T.,Barale Karen V.,Chen Chu,Feng Ziding,Potter John D.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference50 articles.

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2. Rojas,M., Alexandrov,K., Cascorbi,I., Brockmöller,J., Likhachev,A., Pozharisski,K., Bouvier,G., Auburtin,G., Mayer,L., Kopp-Schneider,A., Roots,I. and Bartsch,H. ( 1998 ) High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/MspI-GSTM1*0/*0 genotypes. Pharmacogenetics , 8 , 109 –118.

3. Mollerup,S., Ryberg,D., Hewer,A., Phillips,D.H. and Haugen,A. ( 1999 ) Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients. Cancer Res. , 59 , 3317 –3320.

4. Boobis,A.R., Lynch,A.M., Murray,S., de la Torre,R., Solans,A., Farre,M., Segura,J., Gooderham,N.J. and Davies,D.S. ( 1994 ) CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is the major route of metabolism in humans. Cancer Res. , 54 , 89 –94.

5. Guengerich,F.P., Shimada,T., Yun,C.H., Yamazaki,H., Raney,K.D., Thier,R., Coles,B. and Harris,T.M. ( 1994 ) Interactions of ingested food, beverage and tobacco components involving human cytochrome P4501A2, 2A6, 2E1 and 3A4 enzymes. Environ. Health Perspect. , 102 (suppl. 9) , 49 –53.

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