High frequency of codon 61 K-ras A→T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene-Reference-Cited by-同舟云学术

High frequency of codon 61 K-ras A→T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene

Published:1999-04 Issue:4 Volume:20 Page:657-662
ISSN:1460-2180
Container-title:Carcinogenesis
language:en
Short-container-title:

Author:

Sills R.C.,Hong H.L.,Melnick R.L.,Boorman G.A.,Devereux T.R.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference49 articles.

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2. Melnick,R.L., Sills,R.C., Roycroft,J.H., Chou,B.J., Ragan,H.A. and Miller,R.A. (1994) Isoprene, an endogenous hydrocarbon and industrial chemical, induces multiple organ neoplasia in rodents after 26 weeks of inhalation exposure. Cancer Res., 54, 5333–5339.

3. Melnick,R.L., Roycroft,J.H., Chou,B.J., Ragan,H.A. and Miller,R.A. (1990) Inhalation toxicology of isoprene in F344 rats and B6C3F1 mice following two-week exposures. Environ. Health Perspect., 86, 93–98.

4. Owen,P.E., Glaister,J.R., Graunt,I.F. and Pullinger,D.H. (1987) Inhalation toxicity studies with 1,3-butadiene. Two-year toxicity/carcinogenicity studies in rats. Am. Ind. Hyg. Assoc. J., 48, 407–413.

5. IARC (1987) Chloroprene and Polychloroprene, Some Monomers, Plastics and Synthetic Elastomers and Acrolein. IARC Monographs vol. 19, IARC, Lyon, pp. 131–156.

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