Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes

Author:

Jeng J.H.,Ho Y.S.,Chan C.P.,Wang Y.J.,Hahn L.J.,Lei D.,Hsu C.C.,Chang M.C.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference23 articles.

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2. IARC (1985). Betel-quid and areca nut chewing. Monographs on the evaluation of the carcinogenic risk of chemicals to humans. IARC Scientific Publications No. 37, IARC, Lyon, pp. 141–202.

3. Sundqvist,H., Liu,Y., Nair,J., Bartsch,H., Arvidson,H. and Graftstrom,R.C. ( 1989 ) Cytotoxic and genotoxic effect of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Res. , 49 , 5294 –5298.

4. Jeng,J.H., Kuo,M.L., Hahn,L.J. and Kuo,M.Y.P. ( 1994 ) Genotoxic and non-genotoxic effects of betel quid ingredients on oral mucosal fibroblasts in vitro. J. Dent. Res. , 73 , 1043 –1049.

5. Jeng,J.H., Hahn,L.J., Lin,P.R., Chan,C.P., Hsieh,C.C. and Chang,M.C. ( 1999 ) Effects of areca nut, inflorescence piper betle extracts and arecoline on the cytotoxicity, total and unscheduled DNA synthesis of cultured human gingival keratinocytes. J. Oral Pathol. Med. , 28 , 64 –71.

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